Indianapolis Colts vs Buffalo Bills Week 11 Predictions, Picks, Odds, and 2021 NFL Preview

(Photo : Elsa/Getty Images) EAST RUTHERFORD, NEW JERSEY - Josh Allen #17 and Stefon Diggs #14 of the Buffalo Bills celebrate a touchdown in the second quarter against the New York Jets at MetLife Stadium on November 14, 2021 in East Rutherford, New Jersey.

Two AFC teams will lock horns on Sunday in Week 11 as the Indianapolis Colts visit the Buffalo Bills at the Highmark Stadium. The last time these two teams met was in the 2020 postseason, with Buffalo prevailing over Indianapolis, 27-24, in the AFC Wild Card Round. Can Josh Allen replicate that feat in the Colts vs Bills Week 11 showdown? Read on for a breakdown of this much-anticipated AFC matchup.

Indianapolis Colts installed as +7 underdogs

The Indianapolis Colts extended their winning streak to two games with a narrow 23-17 victory over the Jacksonville Jaguars at Lucas Oil Stadium. It was an important win for the Colts, who kept pace with leaders Tennessee Titans in the AFC South standings, trailing them by three games heading into Week 11.

In their latest win, Jonathan Taylor starred for the Colts again, running for 116 yards and a touchdown on 21 carries. He is now tied with injured two-time defending champion Derrick Henry for the league rushing lead, with both star running backs having 937 yards apiece this season.

Jonathan Taylor could not be stopped on this TD 😤

10 carries for 93 yards already 🚨

(via @NFL)pic.twitter.com/eD5hD4kelc
— ESPN (@espn) November 14, 2021

Taylor also made history with Sunday's performance, becoming just the fourth player in the Super Bowl era to record 100 yards from scrimmage and a touchdown in seven consecutive games. However, he will have his work cut out for him against a Buffalo Bills defense that allowed just 70 yards rushing in Week 10 against the Jets.

The Colts started strong against the Jags, scoring the game's first 17 points. They will need to have that same kind of start against the Bills for them to have a chance of recording their third away win this season.

Buffalo Bills enter Week 11 as -7 favorites

The Buffalo Bills will head to their showdown against the Indianapolis Colts with momentum on their side after crushing the New York Jets, 45-17, in Week 10. It was a huge bounce-back win for the Bills, who suffered a gut-wrenching 9-6 loss to the Jacksonville Jaguars after their bye week.

The Bills maintained their half-game lead over the New England Patriots in the AFC East standings with the victory. The Bills finally woke up from their offensive slumber after a meek showing in Week 9, recording 489 total yards against the Jets.

The Bills did most of their damage on the ground, running for 139 yards and four scores. Devin Singletary, Matt Breida, Zack Moss, and Isaiah McKenzie each scored a touchdown for the Bills, who improved to 6-3 this season.

"We don't have to be the best team in the league. We have to be the best team on Sunday playing on the field we're playing on."

Josh Allen discusses the @BuffaloBills' focus each week after today's win over the Jets.

🎤 @SperoDedes & @jayfeely pic.twitter.com/F2Eb4jyMbI
— NFL on CBS 🏈 (@NFLonCBS) November 14, 2021

One guy who needs to step up for the Bills in the game against Indianapolis is Josh Allen. He completed 21 of 28 passes for 366 yards with two touchdowns and one interception in the win against the Jets. That was a new season-high in passing yards for Allen, who has thrown multiple touchdown passes in seven games for the Bills this season.